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And its not a make any difference of metabolism since it is presently the Lively metabolite of tramadol. Although I've a permatolerance, even when I have never had opioids in my process I'm able to hardly experience 20mg.Apr 5, 2019 #1 Hey there fellas, I am planning on venturing into the world of investigation chem opioids- namely O-DSMT or O-Desm